Nitrosamines and human cancer—Banbury Report 12
نویسندگان
چکیده
منابع مشابه
Relevance of nitrosamines to human cancer.
It is now about three decades since the hepatocarcinogenic effect of N-nitrosodimethylamine (NDMA)* was demonstrated in rats (1) and the suggestion was made that N-nitrosamines can be formed following nitrosation of various amines (2). Direct proof that such nitrosation reactions can occur was provided by Ender et al. (3) who identified NDMA in nitrite preserved fish-meal, and by Sander and Sei...
متن کاملAbsence of Volatile Nitrosamines in Human Feces1
Using a method for nitrosamine analysis that gives high recovery values and that is free from artifactual synthesis of nitrosamines, we have shown that human feces do not contain volatile nitrosamines (detection limit, 0.1 to 0.5 /ng/kg). We also showed that nitrosation reactions are not catalyzed by fecal organisms. Following a 2-day anaerobic incubation of feces with either a secondary aminé...
متن کاملMetabolism of N-nitrosamines by cultured human and rat esophagus.
The metabolism of several N-nitrosamines (N-nitrosodimethylamine, N-nitrosoethylmethylamine, N-nitrosodiethylamine, N-nitrosobenzylmethylamine, and N-nitrosopyrrolidine) in cultured human and rat esophagus has been investigated by measuring (a) CO2, (b) metabolites with an oxo group, and (c) metabolites bound to DNA. Both acyclic and cyclic N-nitrosamines were metabolized by rat esophagus. The ...
متن کاملNitrosamines and Aromatic Amines
A new method for the simultaneous determination of hemoglobin adducts from aromatic amines and tobacco-specific nitrosamines (TSNA) is described. After mild base-catalysed hydrolysis releasing aromatic amines and the TSNA adduct 4-hydroxy-1-(3-pyridyl)-1butanone (HPB), the extraction, cleanup, and concentration are performed by a one-step procedure using C 1 8 cartridges. Determination in the p...
متن کاملNitrosamines and nitramines
2. Furthermore, NIPH was asked by Klif to evaluate existing risk estimates for Nnitrosodimethylamine (NDMA). This includes an evaluation of EPA/IRIS risk estimates for drinking water and air, and other risk estimates of this nitrosamine in Europe or Canada. Klif wanted an evaluation of the validity of the values, how they can be used, and how they should be interpreted. NIPH was also asked to c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1983
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1983.216